| Ecosystem | Type | Status | Ref. |
|---|---|---|---|
| Great Lakes | Lake | native | 5723 |
| James River | River (basin) | native | 86798 |
| Nearctic | Zoogeographic realm | endemic | 5723 |
| Ohio River | River (basin) | native | 86798 |
| Santee River | River (basin) | native | 86798 |
| Savannah River | River (basin) | native | 86798 |
| Susquehanna River | River (basin) | native | 86798 |
| Tennessee River | River (basin) | native | 10294 |